Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function
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چکیده
منابع مشابه
Hypoxia and hypoxia-inducible factors: master regulators of metastasis.
Hypoxia is a common condition found in a wide range of solid tumors and is often associated with poor prognosis. Hypoxia increases tumor glycolysis, angiogenesis, and other survival responses, as well as invasion and metastasis by activating relevant gene expressions through hypoxia-inducible factors (HIF). HIF-1α and HIF-2α undergo oxygen-dependent regulation, and their overexpression is frequ...
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Low oxygen concentrations or hypoxia is a trait common to inflamed tissues. Therefore it is not surprising that pathways of hypoxic stress response, largely governed by hypoxia-inducible factors (HIF), are highly relevant to the proper function of immune cells. HIF expression and stabilization in immune cells can be triggered not only by hypoxia, but also by a variety of stimuli and pathologica...
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ژورنال
عنوان ژورنال: Immunologic Research
سال: 2012
ISSN: 0257-277X,1559-0755
DOI: 10.1007/s12026-012-8349-8